期刊
BIOLOGICAL PSYCHIATRY
卷 60, 期 3, 页码 288-295出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.10.019
关键词
ovarian hormones; progesterone; serotonin; TPH2; dorsal raphe; median raphe
资金
- NIMH NIH HHS [MH63303] Funding Source: Medline
Background. Ovarian steroids modulate anxiety behavior, perhaps by regulating the serotonergic neurons in the midbrain raphe nucleus. The regulation of the brain-specific isoform of rat tryptophan hydroxylase (7PH2) by ovarian hormones has not yet been investigated. Therefore, we examined the effects of estrogen and progesterone on TPH2 mRNA in the rat dorsal and median raphe nuclei (DRN and MRN, respectively) and whether TPH2 mRNA levels correlated with anxiety behavior. Methods: Ovariectomized rats were treated for two, weeks with placebo, estrogen orestrogen plus progesterone, exposed to the open field test, and TPH2 mRNA was quantified by in situ hybridization histochemistry. Results. Estrogen increased TPH2 mRNA in the mid-ventromedial and caudal subregions of the DRN and the caudal MRN. Combined estrogen and progesterone treatment did not change TPH2 mRNA relative to ovariectomized controls. TPH2 mRNA in caudal DRN was associated with lower anxiety-like behavior, whereas 7PH2 mRNA in rostral dorsomedial DRN was associated with increased anxiety-like behavior. Conclusions: These results suggest that estrogen may increase the capacity for serotonin synthesis in discrete subgroups of raphe neurons, and reinforce previous observations that different subregions of DRN contribute to distinct components of anxiety behavior.
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