期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 50, 期 8, 页码 2860-2862出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00303-06
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The distribution and resistance levels of 189 in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants of Beijing and other genotypes were determined. Apart from a higher amount of codon 522 point mutations and large deletions, a spread of mutations similar to that reported for clinical isolates was seen. Most mutations were correlated with high-level resistance; a lower level, or a MIC of < 16 mg/liter, was associated with codon 522 mutations. Multiple mutations were detected in two Beijing mutants.
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