期刊
JOURNAL OF VIROLOGY
卷 80, 期 15, 页码 7781-7785出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00481-06
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- NHLBI NIH HHS [P01 HL051746, P01 HL 59312, P01 HL059312, P01 HL 51746] Funding Source: Medline
During infection, adenovirus-associated virus (AAV) undergoes microtubule-dependent retrograde transport as part of a program of vectorial transport of viral genome to the nucleus. A microtubule binding assay was used to evaluate the hypothesis that cytoplasmic dynein mediates AAV interaction with microtubules. Binding of AAV serotype 2 (AAV2) was enhanced in a nucleotide-dependent manner by the presence of total cellular microtubule-associated proteins (MAPs) but not cytoplasmic dynein-depleted MAPs. Excess AAV2 capsid protein prevented microtubule binding by AAV serotypes 2, 5, and rh.10, as well as adenovirus serotype 5, indicating that similar binding sites are used by these viruses.
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