期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 21, 期 8, 页码 1288-1296出版社
WILEY
DOI: 10.1359/JBMR.060502
关键词
ADAM12; bone growth; chondrocytes; metalloprotease; integrins
ADAM12-S transgenic mice exhibit a pronounced increase in the length of bones, such as femur, tibia, and vertebrae. The effect of ADAM12-S on longitudinal bone growth involves the modulation of chondrocyte proliferation and maturation, likely through proteolytic activities and altered cell-extracellular matrix interactions in the growth plate.
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