期刊
NEUROBIOLOGY OF AGING
卷 27, 期 8, 页码 1145-1154出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2005.06.009
关键词
axonal degeneration; surface ENG; peroneal CMAP; muscle density; sarcopenia
资金
- Intramural NIH HHS [Z99 AG999999] Funding Source: Medline
- PHS HHS [916413, 821336] Funding Source: Medline
Using data from InCHIANTI, a prospective population-based survey of older persons, we examined the relationship of peroneal nerve conduction velocity (NCV a measure of nerve myelination) and compound muscle action potential (CMAP, a measure of axonal degeneration) with calf muscle mass and density, two complementary measures of sarcopenia. NCV and CMAP were assessed by surface electroneurography of the right peroneal nerve conducted in 1162 participants, 515 men and 647 women, age 21-96 years, free of major neurological diseases. Cross-sectional muscle area and calf muscle density were measured using peripheral quantitative computerized tomography (pQCT). Both nerve and muscle parameters declined with age although in most cases the decline was not linear. In both sexes, CMAP, but not NCV, was independently and significantly associated with calf muscle density. These findings suggest that intrinsic changes in the muscle tissue are partially caused by a reduction in the number of motor axons. (c) 2005 Published by Elsevier Inc.
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