期刊
JOURNAL OF VIROLOGY
卷 80, 期 15, 页码 7765-7768出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00542-06
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资金
- NIAID NIH HHS [P30 AI036211, AI 35381, R56 AI035381, R01 AI047725, R56 AI047725, P30 AI 036211, AI 47725, R01 AI035381] Funding Source: Medline
Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes. We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated HIV-1 infections. The great majority of integration sites in each tissue were within genes. Statistical analyses of the frequencies of integration in genes in PBMCs and lymph tissue demonstrated a strong preference for integration within genes. Although the sample size for brain tissue was too small to demonstrate a clear statistical preference for integration in genes, four of the five integration sites identified in brain were within genes. Taken together, our data indicate that HIV-1 preferentially integrates within genes during untreated infection.
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