期刊
CHIRALITY
卷 18, 期 8, 页码 575-580出版社
WILEY
DOI: 10.1002/chir.20282
关键词
asymmetric catalysis; aziridination; bisoxazoline; diene; nitrene
The asymmetric aziridination of 1,3-dienes catalyzed by bisoxazoline-CuOTf complexes with PhI=NTs as a nitrene precursor has been achieved in moderate yields with up to > 99:1 regioselectivity, up to > 99% diastereoselectivity, and up to 80% enantioselectivity. alpha,beta,gamma,delta-Unsaturated ketones usually produced cis-gamma,delta-aziridinated products; while 1,4-diphenyl-1,3-butadiene afforded both of cis- and traps-aziridine derivatives as major products by the use of different bisoxazoline ligands. The configuration of cis-aziridine derivatives was proposed on the basis of the reaction mechanism.
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