期刊
CEREBRAL CORTEX
卷 16, 期 8, 页码 1232-1238出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhj064
关键词
cortex; gender; gray; lateralization; sex difference
资金
- NCRR NIH HHS [P41 RR013642, RR19771, U54 RR021813, M01 RR000865] Funding Source: Medline
- NIBIB NIH HHS [EB01561, P01 EB001955] Funding Source: Medline
- NIMH NIH HHS [MH14584] Funding Source: Medline
- NLM NIH HHS [R01 LM05639] Funding Source: Medline
Using magnetic resonance imaging and computational cortical pattern matching methods, we analyzed hemispheric differences in regional gray matter thickness across the lateral and medial cortices in young, healthy adults (n = 60). In addition, we investigated the influence of gender on the degree of thickness asymmetry. Results revealed global and regionally specific differences between the two hemispheres, with generally thicker cortex in the left hemisphere. Regions with significant leftward asymmetry were identified in the precentral gyrus, middle frontal, anterior temporal and superior parietal lobes, while rightward asymmetry was prominent in the inferior posterior temporal lobe and inferior frontal lobe. On the medial surface, significant rightward asymmetries were observed in posterior regions, while significant leftward asymmetries were evident from the vicinity of the paracentral gyrus extending anteriorly. Asymmetry profiles were similar in both sexes, but hemispheric differences appeared slightly pronounced in males compared with females, albeit a few regions also indicated greater asymmetry in females compared with males. Hemispheric differences in the thickness of the cortex might be related to hemisphere-specific functional specializations that are possibly related to behavioral asymmetries.
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