期刊
NATURE GENETICS
卷 38, 期 8, 页码 948-952出版社
NATURE RESEARCH
DOI: 10.1038/ng1841
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资金
- Biotechnology and Biological Sciences Research Council [D20300, D20300/2] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [D20300/2, D20300] Funding Source: Medline
A major component in the regulatory network controlling fruit ripening is likely to be the gene at the tomato Colorless nonripening (Cnr) locus(1,2). The Cnr mutation results in colorless fruits with a substantial loss of cell-to-cell adhesion. The nature of the mutation and the identity of the Cnr gene were previously unknown. Using positional cloning and virus-induced gene silencing, here we demonstrate that an SBP-box (SQUAMOSA promoter binding protein-like) gene resides at the Cnr locus. Furthermore, the Cnr phenotype results from a spontaneous epigenetic change in the SBP-box promoter. The discovery that Cnr is an epimutation was unexpected, as very few spontaneous epimutations have been described in plants(3,4). This study demonstrates that an SBP-box gene is critical for normal ripening and highlights the likely importance of epialleles in plant development and the generation of natural variation.
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