期刊
MAGNETIC RESONANCE IN MEDICINE
卷 56, 期 2, 页码 240-246出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.20961
关键词
relaxation time; hyperbaric oxygenation; tumor hypoxia; MRI; T-1
资金
- Intramural NIH HHS Funding Source: Medline
Enhancement of image intensity, using the T-1-weighted spoiled gradient-echo (SPGR) sequence, was measured in SCC tumor implanted in the flank of C3H mice while they were subjected to several types of oxygenation challenges inside a hyperbaric chamber designed and constructed to fit in an MRI resonator. The central portions of the tumor gave a positive enhancement, while the periphery showed signal reduction during both normobaric (NBO) and hyperbaric (HBO) oxygen challenges. In the contralateral normal leg, nearly 70% of the region showed a decrease in intensity, and the rest showed a positive enhancement. The positive signal enhancement was markedly greater under HBO compared to NBO. Calculated R-1, R-2, and M-0 maps from multivariate fitting of images acquired by a multislice multiecho (MSME) sequence with variable TR before, during, and after HBO treatment confirm that the source of SPGR signal enhancement in the tumor is associated with shortening of T-1.
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