期刊
MULTIPLE SCLEROSIS JOURNAL
卷 12, 期 4, 页码 369-374出版社
SAGE PUBLICATIONS LTD
DOI: 10.1191/1352458506ms1290oa
关键词
common marmoset; EAE; multiple sclerosis
Pathomorphological studies described pathological heterogeneity in patients with multiple sclerosis (MS). Different effector mechanisms might therefore be responsible for lesion formation in MS. The present report shows that myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in common marmoset monkeys reflects one specific lesional subtype of MS, namely MS pattern 11 lesions with antibody/complement-mediated damage. MOG-induced EAE in marmoset monkeys will, therefore, provide an ideal model for therapeutic approaches directed against B-cell/antibody/complement in MS.
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