Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study

Background. Xerostomia is a ubiquitous complication after conventional radiotherapy for nasopharyngeal carcinoma (NPC) that seriously impairs patient quality of life (OOL). The effect on OOL of parotid-sparing intensity-modulated radiotherapy (IMRT) for early-stage NPC was assessed prospectively. Methods. Thirty-two patients with T1-2,N0-1,M0 NPC received IMRT. Saliva flow was measured, and the Medical Outcomes Short Form 36 (SF-36), European Organization for Research and Treatment of Cancer (EORTC) core, and EORTC head and neck module (QLQ-H&N35) questionnaires were completed at baseline and 2. 6, and 12 months after IMRT. Results. Saliva flow recovered to at least 25% of baseline in most cases after 1 year. Physical function, fatigue, and vitality were problems at 2 months and then resolved (p < .002). Global health scales showed continuous improvement in COIL after treatment (p < .004). Xerostomia and sticky saliva were problems 2 months after treatment; thereafter, continuous improvement occurred (p < .001). Xerostomia scores correlated with general aspects of COIL (p < .044). Conclusion. IMRT for early-stage disease preserved key aspects of COIL, and a reduction in xerostomia symptoms enhanced broader aspects of QOL. (c) 2006 Wiley Periodicals, Inc.