期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 15, 页码 3891-3895出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.05.038
关键词
synthesis; macrocycles; oxazoles; G-quadruplex; cytotoxicity
资金
- NCI NIH HHS [CA097123, CA098127] Funding Source: Medline
- NCRR NIH HHS [P41RR0954] Funding Source: Medline
The synthesis of 24-membered macrocycles containing four, six, and seven oxazole moieties is described. Selected compounds were evaluated for their ability to specifically bind and stabilize G-quadruplex DNA and for cytotoxic activity. An unexpected oxidative cleavage reaction afforded a macrocyclic imide that was also evaluated for G-quadruplex stabilizing and cytotoxic activity. (c) 2006 Elsevier Ltd. All rights reserved.
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