An improved route to the synthetic of diphenyl α-(diethoxythiophosphorylamino) methylphosphonates

An improved method for the synthesis of Diphenyl alpha-(diethoxythiophosphorylamino)methylphosphonates under mild conditions is described. It consists of the reaction of diethyl thiophosphoramidate (1) with triphenyl phosphite (3) and a substituted benzylaldehyde or ketone (2) by a one-pot procedure with the aid of acetyl chloride. (c) 2006 Elsevier Inc. All rights reserved.