期刊
CURRENT OPINION IN PHARMACOLOGY
卷 6, 期 4, 页码 379-386出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2006.01.010
关键词
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资金
- NCI NIH HHS [P30 CA 21765] Funding Source: Medline
Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is only beginning to be understood and could be a way to regulate inflammation by pharmacological agents.
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