期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1761, 期 8, 页码 812-826出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2006.07.002
关键词
peripheral protein; electrostatics; protein/membrane interaction; phosphoinositide; computational biology; electrostatic switch; lateral organization
资金
- NIAID NIH HHS [AI54167] Funding Source: Medline
- NIGMS NIH HHS [GM66147] Funding Source: Medline
Many experimental, structural and computational studies have established the importance of nonspecific electrostatics as a driving force for peripheral membrane association. Here we focus on this component of protein/membrane interactions by using examples ranging from phosphoinositide signaling to retroviral assembly. We stress the utility of the collaboration of experiment and theory in identifying and quantifying the role of electrostatics not only in contributing to membrane association, but also in affecting subcellular targeting, in the control of membrane binding, and in the organization of proteins and lipids at membrane surfaces. (c) 2006 Elsevier B.V. All rights reserved.
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