期刊
NEUROCHEMICAL RESEARCH
卷 31, 期 8, 页码 1055-1058出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-006-9115-x
关键词
calcium; frog; motor nerve terminal; neuro-muscular junction; paired-pulse facilitation; residual Ca2+; transmitter release
High-frequency synaptic activity can cause facilitation of transmitter release due to accumulation of residual Ca2+'' at the nerve terminal. However, the mechanism of this phenomenon is still under debate. Here we show that, using extracellular recording from frog cutaneous pectoris muscle, paired-pulse facilitation (PPF) at the frog neuro-muscular junction decays in two or three-exponential manner depending upon the extracellular Ca2+ concentration ([Ca2+](e)). First, second and early PPF components are analyzed and described in this study. Considering the dependence of PPF on [Ca2+](e), existence of several specific high-affinity intra-terminal Ca2+-binding sites that underlie the facilitation of transmitter release at the frog neuromuscular junction is proposed.
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