期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 31, 期 8, 页码 465-472出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2006.06.006
关键词
-
The structure of the infectious agent responsible for prion diseases has not been fully characterized, but evidence points to a P-rich conformer of the host-encoded prion protein. Amyloid-p peptide (AP), a proteolytic fragment generated from the amyloid precursor protein, has been implicated as the toxic molecule involved in the pathogenesis of Alzheimer's disease. The mechanism of AP toxicity might be mediated through the coordination of redox-active transitionmetal ions such as copper leading to the generation of reactive oxygen species, coupled with the propensity to interact with lipid bilayers. Key sequence and chemical similarities between prion protein (PrP) and Ap indicate that similar therapeutic strategies might be applicable for the treatment of Alzheimer's and prion diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据