期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 15, 页码 5384-5388出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.03.038
关键词
RNA recognition; inhibitors; drug design; HIV-1 RRE
Drugs targeting the stem-loop IIB of Rev responsible element (RRE) of HIV-1 mRNA are potential therapeutic agents for HIV-1 infection. The stem loop is characterized by an internal loop consist of consecutive G-G and G-A mismatches, which is the single binding site for Rev protein for nuclear export of viral mRNA. We report here that ligands binding to G-G and G-A mismatches in duplex DNA also bind to the internal loop in competition with Rev peptide and lead to the dissociation of pre-formed Rev-RRE complex in a model system. (c) 2006 Elsevier Ltd. All rights reserved.
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