期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 15, 页码 3966-3970出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.05.021
关键词
beta-lactam antibiotics; isoxazolidine-3,5-dicarboxylic acids; antibiotic analogs; acylnitroso cycloaddition; hetero Diels-Alder; oxamazin and monobactam analogs
资金
- NIGMS NIH HHS [GM068012] Funding Source: Medline
The structural similarity between beta-lactam antibiotics, such as penicillin, and isoxazolidine-3,5-dicarboxylic acids led to the hypothesis that isoxazolidine-3,5-dicarboxylic acids could be effective analogs of P-lactam antibiotics. The syntheses of relevant isoxazolidine-3,5-dicarboxylic acids from acylnitroso Diels-Alder adducts and subsequent biological testing have shown that these first examples are inhibitors of Escherichia coli X580. (c) 2006 Elsevier Ltd. All rights reserved.
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