期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1758, 期 8, 页码 1117-1125出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2006.03.004
关键词
PKA phosphorylation; channel protein; Rho; cytoskeleton; vasopressin
Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis. However, exact molecular mechanisms which recruit AQP2 are unknown. Recent studies highlighted a key role for spatial and temporal regulation of actin dynamics in AQP2 trafficking. We have recently identified AQP2-binding proteins which directly regulate this trafficking: SPA-1, a GTPase-activating protein (GAP) for Rapt, and cytoskeletal protein actin. In addition, a multiprotein force generator complex which directly binds to AQP2 has been discovered. This review summarizes recent advances related to the mechanism for AQP2 trafficking. (c) 2006 Elsevier B.V. All rights reserved.
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