期刊
BIOCHIMIE
卷 88, 期 8, 页码 943-950出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2006.06.005
关键词
translation; decoding; two-out-of-three reading; tRNA uniformity; tRNA tuning
资金
- NIGMS NIH HHS [GM 37552] Funding Source: Medline
The structure, phylogeny and in vivo function of the base pair formed between nucleotides 32 and 38 of the tRNA anticodon loop are reviewed. The A32-U38 pair, which is highly conserved in tRNA(2)(Ala) and sometimes observed in tRNA(2)(Pro), was recently found to decrease the affinity of tRNAs to the ribosomal A site relative to other 32-38 combinations. This suggests that the role of 32-38 pair is to tune the tRNA affinity in the A site to a uniform value. New experiments presented here show that the U32C mutation in tRNA(1)(Gly) increases its affinity to the cognate codon and to codons with third position mismatches in the A site. This suggests that one reason for uniform tRNA binding to evolve was to avoid incorrect codon recognition. (c) 2006 Elsevier SAS. All rights reserved.
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