期刊
MULTIPLE SCLEROSIS JOURNAL
卷 12, 期 4, 页码 375-385出版社
SAGE PUBLICATIONS LTD
DOI: 10.1191/135248506ms1276oa
关键词
ADAM-17; adhesion molecules; astrocytes; endothelium; multiple sclerosis; TACE; tumour necrosis factor
资金
- Multiple Sclerosis Society [672] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
ADAM-17, a disintegrin and metalloproteinase, is the major proteinase responsible for the cleavage of membrane-bound tumour necrosis factor (TNF) as well as being an active sheddase of other cytokines, cytokine receptors, growth factors and adhesion molecules. TNF is a major proinflammatory cytokine that has been identified as having a pathogenic role in inflammatory diseases within the CNS including multiple sclerosis (MS). Here we report the cellular origin and distribution of ADAM-17 expression within clinically and neuropathologically confirmed MS and normal control white matter, assessed by immunohistochemistry, western blotting and PCR. ADAM-17 expression was associated with the blood vessel endothelium, activated macrophages/microglia and parenchymal astrocytes in MS white matter. Increased levels of ADAM-17 immunoreactivity were displayed in active lesions with evidence of recent myelin breakdown. Further studies into the functional role of ADAM-17 in the pathogenesis of MS and other inflammatory conditions are required.
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