期刊
ANNALS OF HEMATOLOGY
卷 93, 期 9, 页码 1499-1508出版社
SPRINGER
DOI: 10.1007/s00277-014-2069-1
关键词
Acute lymphoblastic leukemia; Bone marrow mesenchymal stromal cells; Drug resistance; Cell cycle; p21
类别
资金
- National High-tech R&D Program of China (863 Program) [N20120221]
- Zhejiang Provincial Natural Science Foundation of China [Y2110152]
The effect of bone marrow microenvironment on the cell cycle of acute lymphocytic leukemia (ALL) and the underlying mechanism has not been elucidated. In this study, we found that in normal condition, bone marrow mesenchymal stromal cells (BM-MSCs) had no significant effect on the cell cycle and apoptosis of ALL; in the condition when the cell cycle of ALL was blocked by genotoxic agents, BM-MSCs could increase the S-phase cell ratio and decrease the G2/M phase ratio of ALL. Besides, BM-MSCs could protect ALL cells from drug-induced apoptosis. Then, we proved that BM-MSCs affect the cell cycle arrest effect of genotoxic agents on ALL cells via p21 down-regulation. Moreover, our results indicated that activation of Wnt/beta-catenin and Erk pathways might be involved in the BM-MSC-induced down-regulation of p21 in ALL cells. Targeting microenvironment-related signaling pathway may therefore be a potential novel approach for ALL therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据