期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 291, 期 2, 页码 G171-G177出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00073.2006
关键词
T2R family; transducin; brush cells; gastrointestinal peptides; enteroendocrine cells
资金
- NIDDK NIH HHS [DK-55003, DK-41301, DK-56930] Funding Source: Medline
Molecular sensing by gastrointestinal (GI) cells plays a critical role in the control of multiple fundamental functions in digestion and also initiates hormonal and/or neural pathways leading to the regulation of caloric intake, pancreatic insulin secretion, and metabolism. Molecular sensing in the GI tract is also responsible for the detection of ingested harmful drugs and toxins, thereby initiating responses critical for survival. The initial recognition events and mechanism(s) involved remain incompletely understood. The notion to be discussed in this article is that there are important similarities between the chemosensensory machinery elucidated in specialized neuroepithelial taste receptor cells of the lingual epithelium and the molecular transducers localized recently in enteroendocrine open GI cells that sense the chemical composition of the luminal contents of the gut.
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