期刊
ANNALS OF HEMATOLOGY
卷 91, 期 1, 页码 27-32出版社
SPRINGER
DOI: 10.1007/s00277-011-1332-y
关键词
Acute myeloid leukemia; Spontaneous remission; Natural killer cells; Disease control
类别
资金
- Forschungs-kommission of the University of Freiburg Medical Center
- Department of Hematology and Oncology, University of Freiburg Medical Center
Spontaneous complete remission (CR) is a rare, poorly understood phenomenon in acute myeloid leukemia (AML). We describe the 10-year follow-up of a patient with MLL-AF9-positive AML (Muller et al. Eur J Haematol 73:62-66, 2004), including ex vivo antileukemic immune responses which may contribute to the long-lasting spontaneous CR (tantamount to cure). We could demonstrate strong in vitro cytotoxic activity mediated by the patient's serum (cryopreserved at diagnosis 2001) against myeloid cell lines. We also addressed cellular cytotoxic activity against myeloid leukemia cells. When the patient's natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control.
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