期刊
EXPERIMENTAL CELL RESEARCH
卷 312, 期 13, 页码 2424-2432出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2006.04.005
关键词
cell migration; fibronectin; gradient; haptotaxis; microvascular endothelial cell; cell polarization; morphology; stochastic
资金
- NHLBI NIH HHS [HL44972] Funding Source: Medline
- NIDDK NIH HHS [DK54932] Funding Source: Medline
The migration of human microvascular endothelial cells (hMEC) was measured on a range of fibronectin gradient slopes. hMEC drift speed increased with increasing gradient slope with no concurrent change in cellular persistence time or random cell speed. The frequency of discrete cellular motion in the gradient direction increased with gradient slope. Morphological polarization of cells on the gradients is also characterized and correlated with cellular drift speed. These experiments present the first demonstration of cellular response to changing haptotactic gradient slope using an in vitro system for the quantitative study of cell migration. (c) 2006 Elsevier Inc. All rights reserved.
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