期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 177, 期 1-2, 页码 85-98出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.04.017
关键词
simian immunodeficiency virus; encephalitis; monocytes; activation markers; cluster of differentiation; flow cytometry
资金
- NIMH NIH HHS [R01 MH071151-04, K24 MH001717, R01 MH071151, K24 MH01717, R01 MH064921, K24 MH001717-09, R01 MH64921] Funding Source: Medline
Lentiviral encephalitis has been hypothesized to be associated with altered monocyte migration into the brain. CD14(hi)/CD16(lo) and CD14(lo)/CD16(hi) monocytes were expanded during acute infection; however, this expansion was not unique or greater in macaques that developed encephalitis. The proportion of monocytes that expressed CD62L, HLA-DR, CD 16, CD64, and CD40 varied during the course of infection in macaques that eventually developed encephalitis. Taken together, these results suggest that changes in the proportion of circulating activated monocytes are not predictive of development of encephalitis, but this does not rule out the importance of activated monocytes in the development of encephalitis. (c) 2006 Elsevier B.V All rights reserved.
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