期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 15, 期 8, 页码 1520-1525出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-06-0270
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资金
- NCI NIH HHS [P30 CA 16086, P30 CA 46592, U01 CA83180, R01 CA098438] Funding Source: Medline
Germ-line mutations of CDKN2A have been identified as strong risk factors for melanoma in studies of multiple-case families. However, an assessment of their relative risk for melanoma in the general population has been difficult because they occur infrequently. We addressed this issue using a novel population-based case-control study design in which cases have incident second- or higher-order melanomas [multiple primary melanoma (MPM)] and controls have incident first primary melanoma [single primary melanoma (SPM)]. Participants were ascertained from nine geographic regions in Australia, Canada, Italy, and United States. In the 1,189 MPM cases and 2,424 SPM controls who were eligible and available for analysis, the relative risk of a subsequent melanoma among patients with functional mutations who have an existing diagnosis of melanoma, after adjustments for age, sex, center, and known phenotypic risk factors, is estimated to be 4.3 (95% confidence interval, 2.3-7.7). The odds ratio varied significantly depending on the type of mutation involved. The results suggest that the relative risk of mutation carriers in the population may be lower than currently believed and that different mutations on the CDKN2A gene may confer substantially different risks of melanoma.
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