期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 17, 期 4, 页码 394-399出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2006.06.008
关键词
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Mass spectrometry is currently at the forefront of technologies for mapping protein-protein interactions, as it is a highly sensitive technique that enables the rapid identification of proteins from a variety of biological samples. When used in combination with affinity purification and/or chemical cross-linking, whole or targeted protein interaction networks can be elucidated. Several methods have recently been introduced that display increased specificity and a reduced occurrence of false-positives. In the future, information gained from human protein interaction studies could lead to the discovery of novel pathway associations and therapeutic targets.
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