期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 116, 期 8, 页码 2142-2151出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI27821
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资金
- NIDDK NIH HHS [R01 DK051362, R56 DK053056, DK51362, DK53056, K08 DK064289, R01 DK044319, R01 DK053056, DK64289, DK44319, R01 DK064351, R37 DK044319, DK64351] Funding Source: Medline
The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. Selective expression of FcRn in the epithelium is shown here to be associated with secretion of IgG into the lumen that allows for defense against an epithelium-associated pathogen (Citrobacter rodentium). This pathway of host resistance to a bacterial pathogen as mediated by FcRn involves retrieval of bacterial antigens from the lumen and initiation of adaptive immune responses in regional lymphoid structures. Epithelial-associated FcRn, through its ability to secrete and absorb IgG, may thus integrate luminal antigen encounters with systemic immune compartments and as such provide essential host defense and immunoregulatory functions at the mucosal surfaces.
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