期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 318, 期 1-2, 页码 146-153出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2006.03.029
关键词
solid-state C-13 NMR; indomethacin; polymorphism
The purpose of this study was to analyze the difference in the molecular conformation packed in the crystal lattice between the meta-stable alpha-form and stable gamma-form of indomethacin on, the basis of solid-state C-13 NMR spectral patterns. The chemical shifts of each resonance of the alpha-form were distinctly different from the gamma-form. Each carbon nucleus of the gamma-form showed a single signal with no splitting. In contrast, carbon nuclei of the alpha-form showed a complicated set of resonances for each carbon. For some carbons of the alpha-form, four signals assigned to one carbon were observed at 203 K. Two of these four signals were merged between the temperature range from 203 to 343 K without a transformation in the crystal structure. It was found that solid-state 13 C NMR can be a powerful tool to estimate the number of molecular conformations as well as configurational differences in the packing of molecules in a unit cell. (c) 2006 Elsevier B.V. All rights reserved.
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