期刊
SCIENCE
卷 313, 期 5787, 页码 644-649出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1121716
关键词
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资金
- NIGMS NIH HHS [R01 GM034985, R37GM34985, P01 GM068087] Funding Source: Medline
- NIMH NIH HHS [MH44651] Funding Source: Medline
The clock gene period-4 (prd-4) in Neurospora was identified by a single allele displaying shortened circadian period and altered temperature compensation. Positional cloning followed by functional tests show that PRD-4 is an ortholog of mammalian checkpoint kinase 2 (Chk2). Expression of prd-4 is regulated by the circadian clock and, reciprocally, PRD-4 physically interacts with the clock component FRQ, promoting its phosphorylation. DNA-damaging agents can reset the clock in a manner that depends on time of day, and this resetting is dependent on PRD-4. Thus, prd-4, the Neurospora Chk2, identifies a molecular link that feeds back conditionally from circadian output to input and the cell cycle.
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