期刊
JOURNAL OF PROTEOME RESEARCH
卷 5, 期 8, 页码 1850-1859出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr060004o
关键词
proteomic; hyperlipidemic; ob/ob mice; Zucker rats; peroxisome proliferator-activated receptor; insulin resistance; rosiglitazone; darglitazone; WY14,643
Zucker fatty rats and ob/ob mice are both frequently used hyperlipidemic and insulin-resistant spontaneous genetic models of obesity. We used them to study the effect of PPAR agonists on the protein-expression level in liver and white adipose tissue. PPARR alpha-agonist treatments of the rats resulted in that 27% of the quantified hepatic proteins were altered; implicating pronounced peroxisome proliferation and increase in capacity for beta-oxidation of fatty acids although no correction of plasma triglycerides were obtained. On treatment with PPAR gamma agonists, adipose proteins were regulated to a much larger extent in the rats compared to mice, 18% and 2%, respectively.
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