Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain

We have identified two novel mouse orexin type-2 receptor (OX2R) splice variants: OX2 alpha R and OX2 beta R. Here, we have mapped in detail the differential gene expression of OX2aR and OX2 beta R in the mouse brain. Using RT-PCR and in situ hybridization, we show that OX2aR is expressed in various areas of the mouse brain and has low expression in caudal part of cerebellum. OX2 beta R is expressed in detectable levels, with the exception of striatum, midbrain and anterior part of cerebellum/pons. Our novel findings demonstrate the differential expression of OX2R splice variants in the mouse brain. (c) 2006 Elsevier B.V. All rights reserved.