期刊
NEUROSCIENCE LETTERS
卷 403, 期 3, 页码 276-279出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.04.053
关键词
naltrexone; opioid antagonist; neuroprotection; Bcl-2 family; Fas signalling; apoptosis
Neuronal loss by apoptosis has been implicated in some neural pathologic disorders. Increasing evidence suggests a neuroprotective effect for opioid antagonists, such as naloxone and naltrexone, in a variety of neural damage experimental models and in the clinic. The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-x(L), Bad and Bax) apoptotic pathways, as well as the active fragment of the executioner caspase-3 in the mouse brain. Western blotting showed that a single injection of naltrexone (1 mg/kg) induced a down-regulation of the pro-apototic proteins Fas, FasL, Bad and Bax. Our results suggest that naltrexone provides neuronal protection against injuries activating either mitochondrial, or death receptor-apoptotic pathways. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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