期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 542, 期 1-3, 页码 179-183出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2006.05.040
关键词
cannabinoid CB2 receptor; itch-associated response; NC mouse
JTE-907,N-(benzo[1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide, is a selective cannabinoid CB2 receptor antagonist/inverse agonist. The anti-pruritic activity of JTE-907 was studied in NC mice with chronic dermatitis, a model of atopic dermatitis. The oral dose of JTE-907 (1 and 10 mg/kg/day), an immunosuppressant agent tacrolimus (I mg/kg/day) and a glucocorticoid betamethasone 17-valerate (I mg/kg/day) for 20 days suppressed the spontaneous scratching and cutaneous nerve activity of NC mice. JTE-907 (10, but not 1, mg/kg) and tacrolimus, but not betamethasone, tended to alleviate the dermatitis. Betamethasone inhibited the body weight gain. These results suggest that JTE-907 suppresses spontaneous itch-associated responses of NC mice without adverse effects such as weight loss. (c) 2006 Elsevier B.V. All rights reserved.
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