期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 542, 期 1-3, 页码 129-135出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2006.06.015
关键词
gomisin A; memory; passive avoidance test; y-maze test; Morris water maze; acetylcholinesterase
Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (I mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance test and the Y-maze test (P < 0.05), and also improved escape latency in the Morris water maze test at 5 mg/kg (P < 0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 mu M). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system. (c) 2006 Published by Elsevier B.V.
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