期刊
FEBS LETTERS
卷 580, 期 18, 页码 4508-4514出版社
WILEY
DOI: 10.1016/j.febslet.2006.07.024
关键词
sodium channel; adaptive insensitivity; scorpion toxins; receptor site; binding properties
Scorpion toxins have been found lacking effect on Na+ current of its own sodium channel, whereas the molecular mechanism remains mystery. In this study, the binding affinity of pharmacologically distinct scorpion toxins was found much weaker to scorpion (Buthus martensii) nerve synaptosomes than to spider (Ornithoctonus huwena) ones. The sodium channel cDNA from these two species were further cloned. The deduced proteins contain 1871 and 1987 amino acids respectively. Several key amino acid substitutions, i.e., A161OV, 11611L and S1617K, are found in lVS3-S4 constituting receptor site-3, and for receptor site-4, two residues (Leu-Pro) are inserted near IIS4 of scorpion sodium channel. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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