期刊
JOURNAL OF CONTROLLED RELEASE
卷 114, 期 1, 页码 69-77出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2006.05.009
关键词
amino acid dendrimer; biodistribution; drug delivery system; nano-carrier; PEGylation
In this study, we synthesized dendritic poly(L-lysine)s (DPKs), dendritic poly(L-ortlithine)s (DPOs), which are constructed as novel amino acid dendrimers, and PEGylated KG6 (the sixth generation of DPKs), and evaluated the physicochemical properties and biodistribution characteristics of these dendrimers. The particle size of DPKs and DPOs was well controlled in the nanometer range. The zeta-potential of these dendrimers was slightly positive and this gradually increased in association with their generation. After intravenous administration to mice, all tested dendrimers cleared rapidly from blood flow and mainly accumulated in the liver and kidney. The hepatic and renal accumulation changed in a generation-dependent manner. In contrast, no significant distributional differences between same generation of DPK and DPO were observed, although the constituent amino acids, particle size, and zeta-potential were different. However, PEGylation of KG6 caused great changes in particle size, zetapotential, blood retention and organ distribution in vivo, indicating that the PEGylation is applicable strategy to improve biodistribution characteristics of dendrimeric molecules. The information provided by this study will be helpful for the development of future drug delivery systems using amino acid dendrimers as safe drug carriers. (c) 2006 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据