期刊
CELL
卷 126, 期 3, 页码 477-487出版社
CELL PRESS
DOI: 10.1016/j.cell.2006.05.051
关键词
-
资金
- Medical Research Council [G8712499] Funding Source: Medline
- NHGRI NIH HHS [R01 HG002772-03, R01 HG002772] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G8712499] Funding Source: researchfish
- MRC [G8712499] Funding Source: UKRI
The transmissible agent causing canine transmissible venereal tumor (CTVT) is thought to be the tumor cell itself. To test this hypothesis, we analyzed genetic markers including major histocompatibility (MHC) genes, microsatellites, and mitochondrial DNA (mtDNA) in naturally occurring tumors and matched blood samples. In each case, the tumor is genetically distinct from its host. Moreover, tumors collected from 40 dogs in 5 continents are derived from a single neoplastic clone that has diverged into two subclades. Phylogenetic analyses indicate that CTVT most likely originated from a wolf or an East Asian breed of dog between 200 and 2500 years ago. Although CTVT is highly aneuploid, it has a remarkably stable genotype. During progressive growth, CTVT down-modulates MHC antigen expression. Our findings have implications for understanding genome instability in cancer, natural transplantation of allografts, and the capacity of a somatic cell to evolve into a transmissible parasite.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据