期刊
GENES & DEVELOPMENT
卷 20, 期 16, 页码 2208-2213出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.381906
关键词
pancreas; spleen; Bapx1(Nkx3.2); metaplasia; cyst
资金
- Medical Research Council [MC_U127527180, MC_U127584494] Funding Source: Medline
- Medical Research Council [MC_U127584494, MC_U127527180] Funding Source: researchfish
- MRC [MC_U127584494, MC_U127527180] Funding Source: UKRI
During early stages of pancreatic development, the mesenchyme that contributes to the spleen overlies the dorsal pancreatic endoderm. Here, we show that interactions between splenic mesenchyme and pancreas proceed via a highly orchestrated morphogenetic program. Disruption of morphogenesis, as occurs in the Bapx1(Nkx3.2)(-/-) embryo, results in transformation of these tissues into well-organized, ectopic gut-like structures. Bapx1 plays a crucial organizing role effecting position and separation of the spleen and pancreas to prevent this metaplastic transformation. Similar transformations occur in organ cultures employing wild-type pancreatic endoderm and spleen mesenchyme, revealing the developmental plasticity of the pancreas and that precise spatial and temporal control of tissue interactions are required for development of both organs.
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