期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 51, 期 2, 页码 101-106出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2006.05.023
关键词
iron oxide; superparamagnetic; nanoparticles; contrast agent
We describe in this paper an approach to synthesize superparamagnetic iron oxide nanoparticles in the presence of polymerized lactic acid. The resulted particles consisted of clusters of iron oxide monocrystals, embedded inside the polymer chains. The composite particles synthesized in situ were highly dispersible in aqueous solution with good stability. X-ray diffraction and magnetometer data all confirmed the crystalline structure and super-paramagnetic property of the particles. They exhibited narrow size distribution with hydrodynamic diameters close to 80 nm. In addition, the particles were shown to have abundant surface carboxyl groups, which can be used to conjugate various biomolecules. Such a preparation would be especially useful for developing target specific MRI contrast agents or drug delivery vehicles. (C) 2006 Published by Elsevier B.V.
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