期刊
BIOINFORMATICS
卷 22, 期 16, 页码 1979-1987出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btl328
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资金
- NCI NIH HHS [CA-21765] Funding Source: Medline
- NIGMS NIH HHS [U01 GM61374, U01 GM61393] Funding Source: Medline
Motivation: Presently available methods that use p-values to estimate or control the false discovery rate (FDR) implicitly assume that p-values are continuously distributed and based on two-sided tests. Therefore, it is difficult to reliably estimate the FDR when p-values are discrete or based on one-sided tests. Results: A simple and robust method to estimate the FDR is proposed. The proposed method does not rely on implicit assumptions that tests are two-sided or yield continuously distributed p-values. The proposed method is proven to be conservative and have desirable large-sample properties. In addition, the proposed method was among the best performers across a series of 'real data simulations' comparing the performance of five currently available methods.
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