期刊
ANNALS OF EPIDEMIOLOGY
卷 24, 期 12, 页码 915-919出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2014.09.007
关键词
Pregnancy; Lead; Preterm birth; Birthweight
资金
- National Institutes of Health [K24 HD069408, R01 ES016314, RO1 HD 034568]
- March of Dimes Foundation [20-FY03-27]
- Harvard Pilgrim Health Care Foundation
Purpose: Maternal lead exposure is associated with poor birth outcomes in populations with moderate to high blood levels. However, no studies have looked at exposure levels commonly experienced by US women. Methods: We evaluated the relationship between maternal red blood cell (RBC) lead levels in mid-pregnancy and birth outcomes in 949 mother-child pairs in a prebirth cohort. We used multiple linear regression and logistic regression, adjusted for potential confounders including maternal age, race, prepregnancy body mass index, and smoking to relate maternal lead to infant birth size and risk for preterm birth (<37 weeks). Results: Mean RBC lead level was 1.2 mu g/dL (range, 0.0-5.0). Mean (standard deviation) birthweight was 3505 (520) g, birthweight for geitational age z-score 0.22 (0.93), and length of gestation 39.5 (1.7) weeks. Mothers in the highest versus lowest lead quartile did not have higher odds (OR, 1.85; 95% confidence interval [CI], 0.79-434) of preterm delivery; after stratifying by child sex, there was an association among males (OR, 5.51; 95% Cl, 1.21-25.15) but not females (OR, 0.82; 95% Cl, 0.24-2.85). Maternal RBC lead was not associated with any continuous outcomes in combined or sex-stratified analyses. Conclusions: Maternal lead exposure, even at very low levels, may adversely affect some childbirth outcomes, particularly preterm birth among males.(C) 2014 Elsevier Inc. All rights reserved.
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