期刊
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
卷 64, 期 3, 页码 665-672出版社
WILEY
DOI: 10.1002/prot.21030
关键词
F-spondin; TSR; extracellular matrix; neuron development; NMR structure
F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NAIR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, non-globular shape, consisting of two P-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures.
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