期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 16, 页码 4395-4399出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.05.048
关键词
indenoisoquinoline; topoisomerase I inhibitor; anticancer; hollow fiber assay
资金
- NCI NIH HHS [U01 CA89566, N01-CO-56000, ST32 CA09634-12] Funding Source: Medline
The indenoisoquinolines are a novel class of non-camptothecin topoisomerase I (Top1) inhibitors whose mechanism of action involves trapping the covalent complex formed between DNA and Top I during cellular processes. As an ongoing evaluation of the indenoisoquitiolines for Top1 inhibition and anticancer activity, indenoisoquinoline analogs have been screened in the National Cancer Institute's hollow fiber assay (HFA). Some of the derivatives demonstrated significant activity at intraperitoneal and subcutaneous fiber placement sites, along with net cancer cell kill in one or more cell lines. (c) 2006 Elsevier Ltd. All rights reserved.
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