期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 16, 页码 5616-5624出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.04.030
关键词
2,6-di-tert-butylphenol derivatives; antioxidants; antiinflammatory agents; cyclooxygenase; lipoxygenase inhibition
Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol. (c) 2006 Elsevier Ltd. All rights reserved.
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