期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 71, 期 17, 页码 6351-6356出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo060351h
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资金
- NIAID NIH HHS [R01 AI050888-04, R01 AI050888, AI-50888] Funding Source: Medline
Two possible isomers of the natural product callipeltin E (1, 5) were synthesized by using an Fmoc-based solid-phase strategy in 7 steps, in 20% and 26% overall yields, respectively. The H-1 NMR spectrum of synthetic 5 correlated closely with that of the natural product, whereas that of 1 did not, providing confirmation of the configurational reassignment of the N-terminal residue of callipeltin E as D-allothreonine. This result strongly implies that the corresponding residue in the closely related cyclic depsipeptides callipeltins A and B should also be considered a D-allothreonine residue.
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