期刊
ANNALS OF EPIDEMIOLOGY
卷 23, 期 7, 页码 415-421出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2013.03.001
关键词
Metabolic syndrome; Adipokines; Cytokines; Inflammatory proteins; Factor analysis; Obesity; Insulin sensitivity
资金
- Medical Research Service of the Department of Veterans Affairs
- Egg Nutrition Center
- Nutrition Obesity Research Center at the University of Washington [DK-035816]
- Diabetes Research Center at the University of Washington [DK-017047]
- General Clinical Research Center [RR-000037]
- Career Development Award from the American Diabetes Association
- NIDDK [DK-080140]
- Dutch Diabetes Foundation
Purpose: Confirmatory factor analysis (CFA) was used to test the hypothesis whether adipocytokines are associated with the risk factor cluster that characterizes the metabolic syndrome (MetS). Methods: Data from 134 nondiabetic subjects were analyzed using CFA. Insulin sensitivity (Si) was quantified using intravenous glucose tolerance tests, visceral fat area by computed tomography and fasting high-density lipoprotein, triglycerides, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A (SAA), tumor necrosis factor (TNF)-alpha, adiponectin, resistin, leptin, interleukin (IL)-6, C-reactive protein (CRP), and plasminogen activator inhibitor (PAI)-1 were measured. Results: The basic model representing the MetS included six indicators comprising obesity, SI, lipids, and hypertension, and demonstrated excellent goodness of fit. Using multivariate analysis, MCP-1, SAA, and TNF-alpha were not independently associated with any of the MetS variables. Adiponectin, resistin, leptin, CRP, and IL-6 were associated with at least one of the risk factors, but when added to the basic model decreased all goodness-of-fit parameters. PAI-1 was associated with all cardiometabolic factors and improved goodness-of-fit compared with the basic model. Conclusions: Addition of PAI-1 increased the CFA model goodness of fit compared with the basic model, suggesting that this protein may represent an added feature of the MetS. Published by Elsevier Inc.
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